Rathbun G A, Heim L R
Toxicon. 1982;20(2):495-9. doi: 10.1016/0041-0101(82)90013-7.
Venom from the Mojave rattlesnake enhanced the antibody mediated hemolytic activity of guinea pig complement when either human or sheep erythrocytes were used as the target cells. Amplification of lytic activity was shown to act in a preferential manner with respect to species of erythrocyte origin. Two steps appear to be necessary for demonstration of enhancement of complement hemolytic activity :(1) interaction of the venom with the complement components; and (2) membrane directed interaction of complement components in association with the active venom factor. These studied extend the findings reported earlier on venom induced complement enhancement.
当使用人或绵羊红细胞作为靶细胞时，莫哈韦响尾蛇的毒液增强了豚鼠补体的抗体介导溶血活性。溶血活性的增强显示出对红细胞来源物种具有优先作用方式。证明补体溶血活性增强似乎需要两个步骤：(1) 毒液与补体成分的相互作用；(2) 补体成分与活性毒液因子相关的膜定向相互作用。这些研究扩展了先前报道的关于毒液诱导补体增强的发现。
