Misawa J, Kanda S, Kokue E, Hayama T, Teramoto S, Aoyama H, Kaneda M, Iwasaki T
Toxicol Lett. 1982 Jan;10(1):51-4. doi: 10.1016/0378-4274(82)90266-1.
Pyrimethamine (PY) was mixed with mashed feed and given to the Göttingen miniature pig (G-mini) during gestional days 11-35. Major malformations such as cleft palate, club-foot and micrognathia were observed in 11 out of 16 newborns from 3 pregnant sows which received 3.6 mg/kg/day. Two sows of a high-dose group (7.2 mg/kg) showed severe anemia and low appetite during the experiment and did not give birth. No malformation was found in 22 newborns of low-dose groups (0.9 and 1.8 mg/kg). Among 130 offspring which died before weaning out of 505 from 47 farrows in a breeding farm, major teratoses such as cleft palate were found in 8 newborns.
在妊娠第11至35天期间，将乙胺嘧啶（PY）与捣碎的饲料混合后喂给哥廷根小型猪（G - mini）。3头怀孕母猪接受3.6毫克/千克/天的剂量，其16头新生仔猪中有11头出现了诸如腭裂、马蹄内翻足和小颌畸形等主要畸形。高剂量组（7.2毫克/千克）的2头母猪在实验期间出现严重贫血和食欲不振，未产仔。低剂量组（0.9和1.8毫克/千克）的22头新生仔猪未发现畸形。在一个养殖场47窝505头仔猪中，有130头在断奶前死亡，其中8头新生仔猪出现了诸如腭裂等主要畸形。
