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Tin decreases femoral calcium independently of calcium homeostasis in rats.

作者信息

Yamaguchi M, Sugii K, Okada S

出版信息

Toxicol Lett. 1982 Jan;10(1):7-10. doi: 10.1016/0378-4274(82)90259-4.

DOI:10.1016/0378-4274(82)90259-4
PMID:7080070
Abstract

Oral administration of stannous chloride (SnCl2) (1.0 mg Sn2$/kg body weight) to rats, twice daily for 28 days, caused a significant increase in the tin (Sn) content and a corresponding decrease of the calcium (Ca) content in the femoral epiphysis, but was without effect on serum Ca, intestinal Ca absorption, and urinary and fecal Ca excretion. The results indicate that in rats Sn directly inhibits bone formation independently of Ca homeostasis.

摘要

相似文献

1
Tin decreases femoral calcium independently of calcium homeostasis in rats.
Toxicol Lett. 1982 Jan;10(1):7-10. doi: 10.1016/0378-4274(82)90259-4.
2
Effect of stannous chloride on rat femur.
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Dose-effect of inorganic tin on biochemical indices in rats.
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Decrease in compressive strength of the femoral bone in rats administered stannous chloride for a short period.短期给予氯化亚锡的大鼠股骨抗压强度降低。
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