镍-63在大鼠体内的分布情况。

Disposition of nickel-63 in the rat.

作者信息

Tandon S K

出版信息

Toxicol Lett. 1982 Jan;10(1):71-3. doi: 10.1016/0378-4274(82)90269-7.

Abstract

The urinary and faecal excretion of nickel-63 (63Ni) and the distribution of 63Ni in kidneys, liver, heart and blood serum after an i.p. injection of radiolabelled nickel chloride (63NiCl2) have been investigated. Most of 63Ni was excreted via urine within 24 h. The daily faecal excretion, though very low, was consistent up to 6 days. The uptake of 63Ni was highest in kidneys and the order was kidneys greater than serum greater than heart greater than liver, 24h after 63NiCl2 injection. However, 63Ni was eliminated rapidly from the body and there was almost no radioactivity 6 days post administration.

摘要

研究了腹腔注射放射性标记的氯化镍（⁶³NiCl₂）后，镍-63（⁶³Ni）的尿粪排泄情况以及⁶³Ni在肾脏、肝脏、心脏和血清中的分布。大部分⁶³Ni在24小时内通过尿液排出。粪便的日排泄量虽极低，但在长达6天的时间内保持稳定。注射⁶³NiCl₂后24小时，肾脏对⁶³Ni的摄取量最高，顺序为肾脏＞血清＞心脏＞肝脏。然而，⁶³Ni从体内迅速消除，给药后6天几乎没有放射性。