Malvaldi G, Chieli E, Pollera M
Toxicol Lett. 1982 Feb;10(2-3):259-63. doi: 10.1016/0378-4274(82)90085-6.
After administration of thiobenzamide (TB) (2.5 mg/100 g b.w.) by stomach tube to male rats, an increase of liver weight was evident within 2 days. It was associated with an increase of hepatic DNA, in the incorporation of [3H]thymidine into nuclei of both hepatocytes and bile duct cells and also in the mitotic index of both types of cells. Liver water content and morphology as well as serum GPT activity were unchanged. In conclusion, TB administration in a single dose below the necrotic threshold stimulates multiplication of liver cells without evidence of damage.
经胃管给雄性大鼠灌胃给予硫代苯甲酰胺（TB）（2.5毫克/100克体重）后，2天内肝脏重量明显增加。这与肝脏DNA增加、[3H]胸腺嘧啶核苷掺入肝细胞和胆管细胞的细胞核以及两种细胞的有丝分裂指数增加有关。肝脏含水量、形态以及血清谷丙转氨酶活性均未改变。总之，以低于坏死阈值的单次剂量给予TB可刺激肝细胞增殖且无损伤迹象。
