半数致死量试验：关于精密度的一些考量

The LD50 test: some considerations of precision.

作者信息

Chanter D O, Heywood R

出版信息

Toxicol Lett. 1982 Feb;10(2-3):303-7. doi: 10.1016/0378-4274(82)90092-3.

Abstract

Substantial improvements in the statistical aspects of the LD50 test are possible. These include modifications to the design of the experiments (including the use of sequential methods) and the replacement of outdated techniques of statistical analysis with more appropriate methods. With such improvements, it would be possible to reduce appreciably the number of animals used (to about 10 or 12) while still achieving precision similar to that obtained with present methods.

摘要

半数致死剂量（LD50）测试的统计学方面有可能得到显著改进。这些改进包括对实验设计的修改（包括使用序贯方法），以及用更合适的方法取代过时的统计分析技术。通过这些改进，有可能大幅减少所用动物的数量（减少到约10只或12只），同时仍能达到与现有方法相近的精度。