[乙醛与牛血清白蛋白的相互作用]
[Interaction of acetaldehyde with bovine serum albumin].
作者信息
Stepuro I I, Zavodnik I B, Ostrovskiĭ Iu M
出版信息
Ukr Biokhim Zh (1978). 1982 Mar-Apr;54(2):123-8.
PMID:7080214
Abstract
At pH 6.8-7.4 acetaldehyde interacts with six primary amino groups of bovine serum albumin to form the Schiff base. Four groups after long incubation most probably interact with imidazole rings of neighbouring hystidine residues to yield cyclic products of substituted aldimines type. The reaction of condensation is described satisfactorily by the second-order equation with the rate constant of 4.5 . 10(-4) M-1 s-1.
摘要
在pH值为6.8 - 7.4的条件下，乙醛与牛血清白蛋白的六个伯氨基相互作用形成席夫碱。经过长时间孵育后，四个基团很可能与相邻组氨酸残基的咪唑环相互作用，生成取代醛亚胺型的环状产物。缩合反应可用二级方程很好地描述，速率常数为4.5×10⁻⁴ M⁻¹ s⁻¹。
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