Cibas P, Padegimas B, Kondrotas A
Allergol Immunopathol (Madr). 1982 Jan-Feb;10(1):17-24.
Patients with mixed, infectious-allergic bronchial asthma and allergodermatoses showed suppression of serotonin metabolism. Allergic reactions in experimental animals were accompanied by changes in the activity of 5-hydroxytryptophandecarboxylase, mitochondrial and blood serum monoaminoxydase, and ceruloplasmin. These changes differed during primary and repeated anaphylactic shock. Quantitative changes in tissue serotonin varied with the activity of the enzymes taking part in its metabolism. During the 1st, 2nd, 5th and 7th days of the post-shock period, serotonin metabolism did not return to normal.
患有混合性感染过敏性支气管哮喘和变应性皮肤病的患者表现出血清素代谢受到抑制。实验动物的过敏反应伴随着5-羟色氨酸脱羧酶、线粒体和血清单胺氧化酶以及铜蓝蛋白活性的变化。这些变化在初次和反复过敏性休克期间有所不同。组织血清素的定量变化随参与其代谢的酶的活性而变化。在休克后第1、2、5和7天，血清素代谢未恢复正常。
