Subirá M L, Oehling A, Diéguez I, Martín-Gil D
Allergol Immunopathol (Madr). 1982 Jan-Feb;10(1):53-60.
A newly developed mode of vaccination with bacterial ribosomal antigens was evaluated in 83 patients with bacterial bronchial asthma. The response of the immune system to two years of immunotherapy was studied by serial determinations, every six months, of the following parameters: E; Ea and EAC rosettes; B-cell surface immunoglobulins; PHA-induced blast transformation, and IgG, IgA, IGM, IgD and IgE immunoglobulins. At basal conditions, patients showed a slight depression in the function of cell-mediated immunity, an increase in Ea rosette formation and decreased values of IgA. After vaccination with ribosomal antigens, an enhanced T-cell response to PHA was observed, followed by normal values of Ea rosettes and increased values of IgA. A statistically significant correlation (p less than 0.001) was evident between Ea rosettes and IgA. Nearly half of the bacterial asthmatic patients in our series presented elevated levels of IgE (greater than 125 U/ml) that remained unchanged even after specific treatment. The immunomodulating action of bacterial ribosomal therapy is discussed.
在83例细菌性支气管哮喘患者中评估了一种新开发的用细菌核糖体抗原进行疫苗接种的方法。通过每六个月连续测定以下参数，研究了免疫系统对两年免疫治疗的反应：E；Ea和EAC玫瑰花结；B细胞表面免疫球蛋白；PHA诱导的母细胞转化，以及IgG、IgA、IGM、IgD和IgE免疫球蛋白。在基础条件下，患者表现出细胞介导免疫功能略有下降，Ea玫瑰花结形成增加，IgA值降低。在用核糖体抗原接种疫苗后，观察到T细胞对PHA的反应增强，随后Ea玫瑰花结值恢复正常，IgA值增加。Ea玫瑰花结与IgA之间存在统计学上显著的相关性（p小于0.001）。在我们的系列研究中，近一半的细菌性哮喘患者IgE水平升高（大于125 U/ml），即使经过特异性治疗仍保持不变。讨论了细菌核糖体疗法的免疫调节作用。
