Howitz P, Platz P
Arch Dis Child. 1978 Aug;53(8):680-2. doi: 10.1136/adc.53.8.680.
21 new cases of infantile spasms were reported in 1976 from paediatric departments in Denmark. The connection between infantile spasms and the Lennox-Gastaut syndrome is mentioned, because of reports of a significantly higher incidence of HLA-B7 in children with Lennox-Gastaut syndrome. The HLA antigen distribution in 19 of the 21 children was compared with that of 1967 healthy adults. No difference in the HLA antigens was demonstrated between children with infantile spasms and controls, whether in the material as a whole, or in the cryptogenic or symptomatic groups. However HLA typing of children with infantile spasms should continue in the search for a potential genetic marker in this grave disease, particularly in view of the reported high incidence of HLA-B7 in children with the Lennox-Gastaut syndrome.
1976年，丹麦各儿科部门报告了21例婴儿痉挛症新病例。文中提到了婴儿痉挛症与伦诺克斯-加斯东综合征之间的联系，因为有报道称，伦诺克斯-加斯东综合征患儿中HLA - B7的发病率显著更高。将这21名儿童中的19名的HLA抗原分布与1967名健康成年人的进行了比较。无论是在整个样本中，还是在隐源性或症状性组中，婴儿痉挛症患儿与对照组之间的HLA抗原均无差异。然而，对婴儿痉挛症患儿进行HLA分型仍应继续，以便在这种严重疾病中寻找潜在的遗传标记，特别是鉴于有报道称伦诺克斯-加斯东综合征患儿中HLA - B7的发病率很高。
