Townsend J C, Bodner K M, Van Peenen P F, Olson R D, Cook R R
Am J Epidemiol. 1982 May;115(5):695-713. doi: 10.1093/oxfordjournals.aje.a113352.
To determine whether paternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or other polychlorinated dioxins might be associated with adverse pregnancy outcomes, an interviewer-administered questionnaire survey was conducted among wives of Dow Michigan Division employees in the Midland, Michigan, area who had been potentially exposed to dioxins. A control group consisted of wives of employees who had no dioxins exposure and whose hire dates were comparable to those of the men in the exposed group. A total of 737 conceptions, which resulted in 637 live births and 10 stillbirths and spontaneous abortions, were identified as having paternal exposure; 2031 conceptions, resulting in 1785 live births and 246 stillbirths and spontaneous abortions, were identified as having no paternal exposure to any isomer of dioxin. Odds ratios were calculated for dependent variables consisting of spontaneous abortions, stillbirths, infant deaths and several categories of congenital malformations. Trend analysis was performed for duration-of-paternal-exposure of 12 months or less, or more than 12 months. Overall, no statistically significant associations were found between any exposure and pregnancy outcome, either before or after stratification by pertinent sets of up to nine covariables.
为了确定父亲接触2,3,7,8 - 四氯二苯并 - 对 - 二恶英（TCDD）或其他多氯二恶英是否可能与不良妊娠结局相关，对密歇根州米德兰地区陶氏化学公司密歇根分部员工的妻子进行了一项由访谈员实施的问卷调查，这些妻子可能接触过二恶英。对照组由未接触二恶英且雇佣日期与接触组男性相当的员工的妻子组成。共确定了737次受孕，其中有637例活产、10例死产和自然流产，这些受孕的父亲有二恶英接触史；2031次受孕，其中有1785例活产、246例死产和自然流产，这些受孕的父亲未接触任何二恶英异构体。计算了由自然流产、死产、婴儿死亡和几类先天性畸形组成的因变量的比值比。对父亲接触时间为12个月或更短、或超过12个月进行了趋势分析。总体而言，在按多达九个相关协变量进行分层之前或之后，未发现任何接触与妊娠结局之间存在统计学上的显著关联。
