Cottle M K, Van Petten G R, van Muyden P
Am J Obstet Gynecol. 1982 May 15;143(2):170-6. doi: 10.1016/0002-9378(82)90649-4.
Phenylephrine and sodium salicylate, separately and in combination, in doses equivalent to the phenylephrine in one "cold" tablet and the sodium salicylate in three aspirins, were infused into conscious, chronically cannulated ewes in the third trimester of pregnancy. Maternal and fetal indices were recorded before (control), during, and after infusion. Phenylephrine depressed uterine blood flow and maternal heart rate (both, 40% below control) and increased maternal mean arterial blood pressure 50%; in the fetus, it depressed arterial blood Po2 (30%) and blood pH, but increased Paco2 and had little effect on mean arterial blood pressure and heart rate. Salicylate alone had no significant effect on maternal and fetal indices, and sodium salicylate plus phenylephrine produced changes similar to those with phenylephrine alone. We conclude that phenylephrine in the maternal circulation could have detrimental effects on the fetus, particularly when fetal Pao2 is depressed as by cord compression during delivery.
将去氧肾上腺素和水杨酸钠单独及联合使用，剂量相当于一片“感冒药”中的去氧肾上腺素和三片阿司匹林中的水杨酸钠，注入处于妊娠晚期、已长期插管的清醒母羊体内。在输注前（对照）、输注期间和输注后记录母羊和胎儿的各项指标。去氧肾上腺素使子宫血流量和母羊心率降低（均比对照低40%），使母羊平均动脉血压升高50%；在胎儿方面，它使动脉血氧分压降低（30%）和血液pH值降低，但使二氧化碳分压升高，对平均动脉血压和心率影响不大。水杨酸钠单独使用对母羊和胎儿各项指标无显著影响，水杨酸钠加去氧肾上腺素产生的变化与单独使用去氧肾上腺素时相似。我们得出结论，母羊循环中的去氧肾上腺素可能对胎儿产生有害影响，尤其是在分娩时因脐带受压导致胎儿动脉血氧分压降低的情况下。
