Gabow P A, Anderson R J, Potts D E, Schrier R W
Arch Intern Med. 1978 Oct;138(10):1481-4.
This study examined the acid-base disturbances in 67 adults with salicylate intoxication. On admission, 66 patients had an acid-base distrubance. In contract to previous suggestions, however, only 25% of the patients had simple respiratory alkalosis. Unlike salicylate intoxication in children, 33% of these adults with salicylate intoxication had ingested additional drugs. These additional drugs generally were CNS depressants and were important determinants of the variety of the acid-base disturbance. Those patients who ingested additional drugs had a significantly lower incidence of respiratory alkalosis (P less than .005) and a higher incidence of respiratory acidosis (P less than .005) and acidemia (P less than 0.25). The incidence of acidemia correlated with the presence of neurological symptoms.
本研究对67例成人水杨酸盐中毒患者的酸碱紊乱情况进行了检查。入院时，66例患者存在酸碱紊乱。然而，与之前的观点相反，只有25%的患者患有单纯性呼吸性碱中毒。与儿童水杨酸盐中毒不同，这些成人水杨酸盐中毒患者中有33%还摄入了其他药物。这些额外摄入的药物通常是中枢神经系统抑制剂，是酸碱紊乱类型的重要决定因素。那些摄入额外药物的患者呼吸性碱中毒的发生率显著较低（P<0.005），呼吸性酸中毒（P<0.005）和酸血症（P<0.25）的发生率较高。酸血症的发生率与神经症状的存在相关。
