Hrushesky W J
Arch Intern Med. 1978 Oct;138(10):1489-91.
Two patients developed severe and symptomatic thrombocytopenia which was clearly related to the every-12-hour subcutaneous administration of heparin sodium. One patient died of hemorrhage while the other patient's platelet count normalized after withdrawal of the therapy. The literature reveals 27 cases of significant thrombocytopenia associated with intravenous heparin administration. In light of the increasing use of low-dose subcutaneous heparin therapy it is important to recognize that this side effect may occur. Periodic platelet counts are recommended for these patients.
两名患者出现严重且有症状的血小板减少症，这显然与每12小时皮下注射肝素钠有关。一名患者死于出血，而另一名患者在停止治疗后血小板计数恢复正常。文献显示有27例与静脉注射肝素相关的显著血小板减少症病例。鉴于低剂量皮下肝素治疗的使用日益增加，认识到这种副作用可能发生很重要。建议对这些患者定期进行血小板计数。
