癫痫患儿中地西泮的直肠吸收情况。
Rectal absorption of diazepam in epileptic children.
作者信息
Dhillon S, Ngwane E, Richens A
出版信息
Arch Dis Child. 1982 Apr;57(4):264-7. doi: 10.1136/adc.57.4.264.
Abstract
The absorption of diazepam after rectal administration was studied in children with epilepsy. When given as a solution, diazepam was rapidly absorbed and produced serum diazepam concentrations above 200 ng/ml within 10 minutes in most children. However, a commercial suppository formulation was absorbed slowly and cannot be recommended for urgent treatment of fits. There is a need in the UK for a rapidly absorbed preparation of diazepam which is approved for rectal use.
摘要
对癫痫患儿直肠给药后地西泮的吸收情况进行了研究。以溶液形式给药时，地西泮吸收迅速，大多数患儿在10分钟内血清地西泮浓度就会超过200纳克/毫升。然而，一种市售栓剂制剂吸收缓慢，不推荐用于惊厥的紧急治疗。英国需要一种经批准可直肠使用的吸收迅速的地西泮制剂。
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