Puttemans F J, Massart D L, Gilles F, Lievens P C, Jonckeer M H
Arch Phys Med Rehabil. 1982 Apr;63(4):176-80.
Physiotherapists often apply electrotherapeutic treatments to the knees with sponges impregnated with potassium iodide (KI). To study the fate of iodine applied in this way, the amount of iodide (I-) that penetrates the skin was determined using an iodide-selective electrode. The I- uptake was shown to take place only when galvanic current was applied. Iontophoresis did not result in superficial migration of the applied ions on the skin from one pole to the other, but led to penetration into the skin. The hyperemia, which occurs at the zone of application during iontophoresis, did not affect the uptake of subsequent treatments. Only very slight differences in uptake were observed for each patient with sequential application, whereas the interindividual differences were more pronounced. Combined evidence from all experiments suggested that about 10% of the applied KI had penetrated the skin. X-ray fluorescence scans of the volunteers' thyroid gland, before and after a series of 10 iontophoretic treatments, to establish whether I- was taken up by the thyroid, showed that the average iodine content of the gland was increased by more than 30%.
物理治疗师经常使用浸有碘化钾（KI）的海绵对膝盖进行电疗。为了研究以这种方式施用的碘的去向，使用碘离子选择性电极测定穿透皮肤的碘离子（I-）量。结果表明，只有在施加直流电时才会发生碘离子摄取。离子电渗疗法不会导致所施加的离子在皮肤上从一极向另一极的表面迁移，但会导致其渗透到皮肤中。离子电渗疗法期间在施用区域出现的充血并不影响后续治疗的摄取。对于每位患者，连续施用时仅观察到摄取量有非常轻微的差异，而个体间差异则更为明显。所有实验的综合证据表明，约10%的施用碘化钾已穿透皮肤。对志愿者进行一系列10次离子电渗疗法前后的甲状腺进行X射线荧光扫描，以确定甲状腺是否摄取了碘离子，结果表明甲状腺的平均碘含量增加了30%以上。
