Owen S R, Boarder M, Gray J A, Fillenz M
Behav Brain Res. 1982 May;5(1):3-9. doi: 10.1016/0166-4328(82)90087-0.
Local injection of 6-hydroxydopamine was used to selectively destroy the dorsal ascending noradrenergic bundle (DB), producing 75% loss of hippocampal noradrenaline. Lesioned and control rats were trained to run in a straight alley for food reward with or without pretraining (handling and habituation to the apparatus). Lesioned rats ran more slowly than controls only if they had not been pretrained. This result may explain previous discrepancies in the literature; it is discussed in relation to existing hypotheses of DB function.
局部注射6-羟基多巴胺用于选择性破坏背侧上行去甲肾上腺素能束（DB），导致海马去甲肾上腺素损失75%。对损伤组和对照组大鼠进行训练，使其在直道中奔跑以获取食物奖励，训练过程中有或没有预训练（对实验装置的处理和适应）。只有在没有经过预训练的情况下，损伤组大鼠的奔跑速度才比对照组慢。这一结果可能解释了文献中先前存在的差异；并结合现有的关于DB功能的假说进行了讨论。
