Fazio M, Airoldi M, Gandolfo S, Mastromatteo V, Negri I, Pecchio F, Sartoris S
Boll Soc Ital Biol Sper. 1982 Apr 15;58(7):412-8.
The authors have evaluated general immunocompetence after cryosurgical treatment of 11 patients affected by benign oral lesions and of 17 patients affected by oral squamous carcinoma. Serum immunoglobulin levels, C3-C4, peripheral lymphocytes, E-rosette forming cells, lymphocyte response to PHA were analyzed before a single cryotreatment and 7 and 14 days after. In the patients affected by benign lesions the observed variations seem to suggest that in these cases cryosurgery has a merely mechanical action of extirpation of the lesion and the consequent extinction of the phenomena reactive to the same lesion. In cancer patients, cryosurgery modifies numerous immunological parameters mostly concerning the cell-mediate components.
作者评估了11例患有口腔良性病变的患者和17例患有口腔鳞状癌的患者在冷冻治疗后的一般免疫能力。在单次冷冻治疗前以及治疗后7天和14天，分析了血清免疫球蛋白水平、补体C3 - C4、外周淋巴细胞、E - 玫瑰花结形成细胞以及淋巴细胞对PHA的反应。在患有良性病变的患者中，观察到的变化似乎表明，在这些病例中冷冻手术仅仅具有切除病变的机械作用，并随之消除了对同一病变的反应性现象。在癌症患者中，冷冻手术改变了许多免疫参数，主要涉及细胞介导成分。
