Zago M A, Bottura C
Blut. 1982 Mar;44(3):159-64. doi: 10.1007/BF00320762.
Globin chain synthesis was studied in 13 iron-deficient patients. The mean whole-cell globin alpha/beta ratio in the peripheral blood of 11 patients was 1.05 +/- 0.06 which is similar to the value 0.99 +/- 0.08 obtained for 10 controls. The ratios obtained for stroma-free globin were not significantly different from those of whole cell preparations. In contrast, the alpha/beta ratio of bone marrow was 0.73 +/- 0.14 in 10 iron deficient patients, which is significantly lower than that of controls. Two other patients had decreased alpha/beta ratios in the peripheral blood, probably because of the presence of an alpha-thalassemia gene. These results demonstrate a reduced rate of synthesis of alpha chains relative to that of beta chains in the bone marrow of iron-deficient patients that is not demonstrable in the peripheral blood.
对13名缺铁患者的珠蛋白链合成进行了研究。11名患者外周血中全细胞珠蛋白α/β的平均比值为1.05±0.06,这与10名对照者的0.99±0.08相近。无基质珠蛋白的比值与全细胞制剂的比值无显著差异。相比之下,10名缺铁患者骨髓的α/β比值为0.73±0.14,显著低于对照者。另外两名患者外周血中α/β比值降低,可能是由于存在α地中海贫血基因。这些结果表明,缺铁患者骨髓中α链的合成速率相对于β链降低,而在外周血中未表现出来。