脊髓5,7 - 二羟基色胺损伤增强足部电击诱导的镇痛作用。

Enhancement of footshock-induced analgesia by spinal 5,7-dihydroxytryptamine lesions.

作者信息

Hutson P H, Tricklebank M D, Curzon G

出版信息

Brain Res. 1982 Apr 15;237(2):367-72. doi: 10.1016/0006-8993(82)90448-6.

DOI:10.1016/0006-8993(82)90448-6

Abstract

The analgesia induced by 30-s footshock (1 mA) is enhanced and attenuated by decreasing and increasing the extraneuronal availability of serotonin (5-HT), respectively. In the present work we have shown the effect to be mediated by spinal 5-HT systems as the response was increased by depletion of spinal but not brain 5-HT following injection of 5,7-dihydroxytryptamine into the spinal cord or raphe magnus. Injection of 5,7-DHT into the medial raphe which depleted brain but not spinal 5-HT was without effect.

摘要

30秒足部电击（1毫安）诱导的镇痛作用分别通过降低和增加血清素（5-羟色胺，5-HT）的细胞外可用性而增强和减弱。在本研究中，我们已表明该效应由脊髓5-HT系统介导，因为在向脊髓或中缝大核注射5,7-二羟色胺后，脊髓而非脑内5-HT的耗竭会增强该反应。向中缝内侧注射5,7-二羟色胺可使脑内而非脊髓内的5-HT耗竭，该操作无此效应。

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