Day T A, Oliver J R, Menadue M F, Davies B, Willoughby J O
Brain Res. 1982 Apr 22;238(1):55-63. doi: 10.1016/0006-8993(82)90770-3.
The role of preoptic/anterior hypothalamic area (PO/AHA) neurones in the regulation of basal patterns of growth hormone (GH) and prolactin (Prl) secretion was investigated in unanesthetized male rats prepared with chronic indwelling venous cannulae. PO/AHA injections of the neurotoxin kainic acid (KA) substantially reduced both GH and Prl secretion. Histological examination of tissue sections indicated that KA treatment had produced extensive neuronal loss and gliosis in the medial (m) but not the periventricular (p) PO/AHA. These findings suggest that m-PO/AHA neurones are facilitatory to the basal secretion of both GH and Prl. It is proposed that GH-facilitatory m-PO/AHA neurones provide an inhibitory input to the GH release-inhibiting factor neurones which are known to reside in the p-PO/AHA. Prl-facilitatory m-PO/AHA neurones may secrete, or stimulate the secretion of a Prl releasing factor.
在通过慢性留置静脉套管制备的未麻醉雄性大鼠中，研究了视前区/下丘脑前区（PO/AHA）神经元在调节生长激素（GH）和催乳素（Prl）基础分泌模式中的作用。向PO/AHA注射神经毒素海人酸（KA）可显著降低GH和Prl的分泌。组织切片的组织学检查表明，KA处理在PO/AHA内侧（m）而非室周（p）区域导致了广泛的神经元丢失和胶质增生。这些发现表明，m-PO/AHA神经元对GH和Prl的基础分泌具有促进作用。有人提出，促进GH分泌的m-PO/AHA神经元向已知位于p-PO/AHA的GH释放抑制因子神经元提供抑制性输入。促进Prl分泌的m-PO/AHA神经元可能分泌或刺激Prl释放因子的分泌。
