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使用嘌呤从头合成的前体加速缺血后犬心肌中ATP和GTP池的补充。

Accelerated repletion of ATP and GTP pools in postischemic canine myocardium using a precursor of purine de novo synthesis.

作者信息

Swain J L, Hines J J, Sabina R L, Holmes E W

出版信息

Circ Res. 1982 Jul;51(1):102-5. doi: 10.1161/01.res.51.1.102.

DOI:10.1161/01.res.51.1.102
PMID:7083487
Abstract

During ischemia, the myocardial content of the purine nucleotides ATP and GTP falls and remains depressed for hours to days. Prolonged depletion of ATP in the postischemic state is accompanied by functional and ultrastructural abnormalities. This report describes the successful use of the purine precursor 5-aminoimidazole-4-carboxamide riboside to selectively enhance the rate of repletion of the ATP and GTP pools in postischemic myocardium.

摘要

在缺血期间，心肌中嘌呤核苷酸三磷酸腺苷（ATP）和三磷酸鸟苷（GTP）的含量下降，并在数小时至数天内持续处于低水平。缺血后状态下ATP的长期消耗伴随着功能和超微结构异常。本报告描述了成功使用嘌呤前体5-氨基咪唑-4-甲酰胺核苷来选择性提高缺血后心肌中ATP和GTP储备的补充速率。

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Circ Res. 1982 Jul;51(1):102-5. doi: 10.1161/01.res.51.1.102.
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