对哮喘患儿的皮肤、鼻子和肺部进行抗原激发试验；速发型和双重过敏反应。
Antigen provocation to the skin, nose and lung, in children with asthma; immediate and dual hypersensitivity reactions.
作者信息
Price J F, Hey E N, Soothill J F
出版信息
Clin Exp Immunol. 1982 Mar;47(3):587-94.
Most (18/21) children with perennial asthma gave dual (immediate and late) responses to bronchial provocation with two of Dermatophagoides pteronyssinus, and either timothy grass pollen or cat fur. Most (19/21) also showed dual responses to skin prick tests, only half (11/21) gave dual responses in the nose, mainly with timothy grass pollen, and these were associated with allergic rhinitis. Only two children gave dual responses in lung, skin and nose to both antigens, and only two gave immediate reactions without late reactions in all positive tests; most showed different patterns of response according to the organ tested or the antigen used for provocation. Our results suggest that local factors may be important in determining the pattern of allergic response in a 'target' organ, and that dual responses are strongly associated with the patient's symptoms.
大多数（18/21）患有常年性哮喘的儿童对两种变应原——屋尘螨以及梯牧草花粉或猫毛进行支气管激发试验时出现双重（速发和迟发）反应。大多数（19/21）儿童对皮肤点刺试验也表现出双重反应，只有一半（11/21）儿童在鼻部出现双重反应，主要是对梯牧草花粉，且这些反应与过敏性鼻炎相关。只有两名儿童在肺部、皮肤和鼻部对两种抗原均出现双重反应，且只有两名儿童在所有阳性试验中仅出现速发反应而无迟发反应；大多数儿童根据所检测的器官或用于激发试验的抗原表现出不同的反应模式。我们的结果表明，局部因素在决定“靶”器官的过敏反应模式中可能很重要，且双重反应与患者症状密切相关。
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