性类固醇对离体兔卵巢卵泡中促黄体生成素刺激的类固醇积累的体外效应。

In vitro effects of sex steroids on LH-stimulated steroid accumulation by isolated rabbit ovarian follicles.

作者信息

Younglai E V

出版信息

Mol Cell Endocrinol. 1982 Apr;26(1-2):223-9. doi: 10.1016/0303-7207(82)90019-3.

Abstract

The in vitro effects of progesterone, testosterone and estradiol-17 beta on steroid accumulation by isolated rabbit follicles were examined. Progesterone had no effect on LH-stimulated androgen accumulation but inhibited LH-stimulated estrogen accumulation at 10(-7) M and 10(-6) M. Testosterone at 10(-5) M but not at 10(-6) M or 10(-7) M, inhibited LH-stimulated progesterone accumulation. LH-stimulated estrogen accumulation was inhibited at all dose levels of testosterone. Estradiol (10(-5) M) inhibited LH-stimulated androgen accumulation and had no effects on progesterone accumulation. It is concluded that the steroidal milieu of follicles can influence their response to LH.

摘要

研究了孕酮、睾酮和雌二醇 -17β 对分离的兔卵泡类固醇积累的体外作用。孕酮对促黄体生成素（LH）刺激的雄激素积累没有影响，但在 10⁻⁷ M 和 10⁻⁶ M 时抑制 LH 刺激的雌激素积累。10⁻⁵ M 的睾酮可抑制 LH 刺激的孕酮积累，而 10⁻⁶ M 或 10⁻⁷ M 则无此作用。在所有睾酮剂量水平下，LH 刺激的雌激素积累均受到抑制。雌二醇（10⁻⁵ M）抑制 LH 刺激的雄激素积累，对孕酮积累没有影响。结论是卵泡的类固醇环境可影响其对 LH 的反应。