Orlando M, Casalbore P, Camagna A, Lauro R, Tardella L, Hassan H J
Haemostasis. 1982;11(2):73-8. doi: 10.1159/000214643.
Factor VII activity and factor VII cross-reacting material (CRM) in plasma of patients with liver cirrhosis have been studied before and after vitamin K1 parenteral administration. Subjects were divided into two groups according to the absence (group I) or the presence (group II) of the following clinical findings: ascites, portal hypertension, encephalopathy. Factor VII activity and CRM show a statistically significant correlation (p less than 0.001) in all patients. In group II, significantly reduced levels of both activity and CRM were found as compared to the reference and the group I values. No variations were found after vitamin K administration. Different thromboplastins, investigated with respect to their sensitivity for factor VII, acted differently. Patients with normal albumin levels also showed normal levels of factor VII activity and antigen. No correlation was found in group II. The data discussed suggest that in liver cirrhosis with unknown aetiology no immunologically detectable precursor of factor VII is present.
对肝硬化患者血浆中的凝血因子 VII 活性和凝血因子 VII 交叉反应物质（CRM）在胃肠外给予维生素 K1 前后进行了研究。根据是否存在以下临床症状将研究对象分为两组：腹水、门静脉高压、肝性脑病（I 组无上述症状，II 组有上述症状）。所有患者的凝血因子 VII 活性和 CRM 呈统计学显著相关性（p < 0.001）。与参照值和 I 组值相比，II 组的活性和 CRM 水平均显著降低。给予维生素 K 后未发现变化。就对凝血因子 VII 的敏感性进行研究的不同凝血活酶，其表现各异。白蛋白水平正常的患者凝血因子 VII 活性和抗原水平也正常。II 组未发现相关性。所讨论的数据表明，病因不明的肝硬化患者不存在免疫可检测的凝血因子 VII 前体。
