Briet E, Reisner H M, Blatt P M
Haemostasis. 1982;11(2):87-9. doi: 10.1159/000214645.
The levels of factors VIII, II, and VII rise during pregnancy in normal women. In addition, increases in factor VIII levels have been observed in pregnant carriers of hemophilia A and in women affected with von Willebrand's disease. The influence of pregnancy on factor IX levels is less clear. Consequently, we determined serial factor IX coagulant activities (IX:C) and factor IX antigen levels (IX:Ag) during the pregnancy of an affected carrier of hemophilia B who had baseline values of 13% both IX:C and IX:Ag levels. Neither level rose during pregnancy and the patient was treated with plasmapheresis and plasma infusions during the delivery and the postpartum period. Excessive bleeding did not occur.
正常女性在孕期时，凝血因子VIII、II和VII水平会升高。此外，在甲型血友病的妊娠携带者以及患有血管性血友病的女性中，也观察到了凝血因子VIII水平的升高。妊娠对凝血因子IX水平的影响尚不清楚。因此，我们测定了一名乙型血友病携带者在孕期的系列凝血因子IX凝血活性（IX:C）和凝血因子IX抗原水平（IX:Ag），该患者的基线IX:C和IX:Ag水平均为13%。孕期这两项指标均未升高，该患者在分娩期和产后期接受了血浆置换和血浆输注治疗。未发生大出血情况。
