Roach M R, Hinton P, Fletcher J
Atherosclerosis. 1978 Sep;31(1):1-10. doi: 10.1016/0021-9150(78)90031-x.
Detailed studies of aortas from 8 rabbits showed that serious artefacts occur if the aortas are pinned at their in vivo dimensions, rather than fixed at physiological pressure. In the pinned aortas, the proximal parts of the branches were pulled up onto the aortic wall. This was more pronounced for the large branches of the abdominal aorta than for the smaller intercostal branches. This artefact caused atherosclerotic lesions, which had developed at the origin of the branch, to appear as if they were entirely on the aortic wall. We found that a marked change in the elastin pattern was present at the origin of the branch; this can be used to mark the true origin of the branch. With the pressure technique we found that lesions had different shapes and locations at different branch points.
对8只兔子的主动脉进行的详细研究表明，如果将主动脉固定在其体内尺寸而非生理压力下，会出现严重的假象。在固定的主动脉中，分支的近端部分被拉到主动脉壁上。腹主动脉的大分支比肋间小分支更明显。这种假象导致在分支起源处发展的动脉粥样硬化病变看起来好像完全在主动脉壁上。我们发现，在分支起源处存在弹性蛋白模式的明显变化；这可用于标记分支的真正起源。通过压力技术，我们发现病变在不同分支点具有不同的形状和位置。
