Tepper J, Rosenberg S A, Glatstein E
Int J Radiat Oncol Biol Phys. 1982 Feb;8(2):263-73. doi: 10.1016/0360-3016(82)90526-0.
We have formulated certain treatment techniques for soft sarcomas of the extremities in adults, based on the experience of treating 75 patients at the National Cancer Institute. Attaining a high likelihood of tumor control is heavily dependent on a variety of factors. These factors include a knowledge of the biological characteristics of the tumor, of the normal tissue anatomy and its relationship to the tumor and of the surgical techniques available and the details of the surgery already performed. Obtaining good long term function in the irradiated extremity is dependent on sparing a strip of soft tissue and using sophisticated radiation therapy techniques. These techniques include casting of the extremity for immobilization, using a variety of gantry and collimator angulations, using treatment planning for determining the necessity for wedges or compensating filters in the radiation field and utilizing secondary collimation. With this highly individualized approach to treatment of patients with soft tissue sarcomas, optimal results can be obtained.
基于美国国立癌症研究所治疗75例患者的经验,我们为成人肢体软组织肉瘤制定了特定的治疗技术。实现高肿瘤控制率在很大程度上取决于多种因素。这些因素包括对肿瘤生物学特性的了解、对正常组织解剖结构及其与肿瘤关系的了解、对可用手术技术以及已实施手术细节的了解。在受照射肢体中获得良好的长期功能取决于保留一条软组织带并使用先进的放射治疗技术。这些技术包括为固定肢体而进行石膏固定、使用各种机架和准直器角度、使用治疗计划来确定放射野中楔形物或补偿滤过器的必要性以及使用二级准直。通过这种针对软组织肉瘤患者的高度个体化治疗方法,可以获得最佳结果。