Akiskal H S
J Clin Psychiatry. 1982 Jul;43(7):266-71.
Factors associated with chronicity in primary depression were investigated. Chronic secondary and episodic primary depressives served as control groups. Shortened REM latency and relative absence of pronounced characterologic pathology in the chronic primary depressive group were similar to data for episodic primary depressive controls. Chronicity in primary depression was significantly correlated with a positive family history of affective disorder, multiple losses through death of family members, disabled spouses, concurrent incapacitating medical diseases (especially their treatment with depressant antihypertensive drugs), and secondary sedativism (including alcoholism). No correlation was found with childhood loss of a parent or severity of depressive episodes.
对原发性抑郁症慢性化相关因素进行了调查。慢性继发性抑郁症患者和发作性原发性抑郁症患者作为对照组。慢性原发性抑郁症组的快速眼动睡眠潜伏期缩短以及相对缺乏明显的性格病理特征，与发作性原发性抑郁症对照组的数据相似。原发性抑郁症的慢性化与情感障碍的阳性家族史、因家庭成员死亡导致的多次丧失、残疾配偶、并发的致残性内科疾病（尤其是使用降压镇静药进行治疗）以及继发性镇静状态（包括酗酒）显著相关。未发现与童年丧父或丧母以及抑郁发作的严重程度存在相关性。
