Aiba S, Minoura N, Fujiwara Y
J Biomed Mater Res. 1982 May;16(3):181-94. doi: 10.1002/jbm.820160302.
This study pertains to the development of poly (alpha-amino acid) membranes which have potential as biomaterials. Copoly (L-alanine, L-methionine) membranes have been subjected to oxidation which produced a hydrophilic structure allowing the improvement of oxygen permeability. L-Methionine residues in the copolymers were converted to methionine sulfoxide and/or sulfone groups by action of hydrogen peroxide in various reaction compositions. Water absorption, permeability to oxygen dissolved in water, and tensile strength of the modified membranes were changed with the extent of oxidation. The water absorption was found to increase with oxidation time from 10 to 300%. The oxidation time dependency on the oxygen permeability coincided with the increase in the water absorption. The permeability coefficients of oxidized membranes were of the order of 10(-9) cm3 (STP) cm/cm2 s cm Hg, while those of unoxidized membranes were approximately 10(-11). As expected, the tensile strengths of oxidized membranes were smaller than those of unoxidized ones. In addition, the effect of L-alanine and L-methionine residue composition on the membrane properties is discussed.
本研究涉及具有生物材料潜力的聚（α-氨基酸）膜的开发。共聚（L-丙氨酸，L-蛋氨酸）膜已进行氧化处理，形成了亲水性结构，从而提高了氧气渗透性。在各种反应组合物中，通过过氧化氢的作用，共聚物中的L-蛋氨酸残基被转化为甲硫氨酸亚砜和/或砜基团。改性膜的吸水率、对溶解在水中的氧气的渗透性以及拉伸强度随氧化程度而变化。发现吸水率随氧化时间从10%增加到300%。氧化时间对氧气渗透性的依赖性与吸水率的增加一致。氧化膜的渗透系数约为10^(-9) cm³（标准温度和压力）·cm/cm²·s·cm Hg，而未氧化膜的渗透系数约为10^(-11)。正如预期的那样，氧化膜的拉伸强度比未氧化膜的小。此外，还讨论了L-丙氨酸和L-蛋氨酸残基组成对膜性能的影响。
