Morison W L, Momtaz K, Parrish J A, Fitzpatrick T B
J Am Acad Dermatol. 1982 Jan;6(1):46-51. doi: 10.1016/s0190-9622(82)70005-2.
Thirty patients with psoriasis were treated with a 3-week course of methotrexate followed by a combination of PUVA therapy and methotrexate. When lesions cleared to less than 1% UVA-exposed body involvement, the methotrexate was stopped and PUVA therapy alone was used as maintenance therapy. This protocol achieved clearance of disease in twenty-eight of the thirty patients in a mean of 5.7 (+/- 1.0) weeks, with 9.3 (+/- 3.0) exposures to PUVA therapy and a final UVA radiation dose at clearance of 6.2 (+/- 2.5) J/cm2. The mean total dose of methotrexate was 93.0 mg (range, 67.5-127.5 mg). The only significant adverse effect seen was prolonged phototoxicity in eight patients. By reducing the total cumulative exposure dose of PUVA therapy, this treatment may reduce long-term side effects.
30例银屑病患者接受了为期3周的甲氨蝶呤治疗，随后采用补骨脂素加长波紫外线（PUVA）疗法与甲氨蝶呤联合治疗。当皮损消退至暴露于UVA的身体部位受累面积小于1%时，停用甲氨蝶呤，仅采用PUVA疗法作为维持治疗。该方案使30例患者中的28例在平均5.7（±1.0）周内疾病清除，接受9.3（±3.0）次PUVA治疗，清除时的最终UVA辐射剂量为6.2（±2.5）J/cm2。甲氨蝶呤的平均总剂量为93.0mg（范围为67.5 - 127.5mg）。唯一观察到的显著不良反应是8例患者出现了延长的光毒性。通过减少PUVA治疗的总累积暴露剂量，这种治疗可能会减少长期副作用。
