不同载体用于局部应用皮质醇时皮肤渗透特性的评估。

Assessment of the skin penetration properties of different carrier vehicles for topically applied cortisol.

作者信息

Ayres P J, Hooper G

出版信息

Br J Dermatol. 1978 Sep;99(3):307-17. doi: 10.1111/j.1365-2133.1978.tb02002.x.

DOI:10.1111/j.1365-2133.1978.tb02002.x

Abstract

Four commercially available topical preparations of cortisol, Alphaderm, Calmurid HC, Efcortelan and Topisone, had trace quantities of tritiated cortisol added to them. The resultant radiolabelled creams were applied to the dorsum of the pig and the penetration of the steroid was assessed. Alphaderm was shown to deliver approximately 16.0 times more cortisol to the skin than Topisone, approximately 8.0 times more than Efcortelan and approximately 3.0 times more than Calmurid HC.

摘要

四种市售的皮质醇外用制剂，即Alphaderm、Calmurid HC、Efcortelan和Topisone，均添加了微量的氚标记皮质醇。将所得的放射性标记乳膏涂抹在猪的背部，并评估类固醇的渗透情况。结果显示，Alphaderm向皮肤输送的皮质醇比Topisone多约16.0倍，比Efcortelan多约8.0倍，比Calmurid HC多约3.0倍。