Riedel W, Kozawa E, Iriki M
J Auton Nerv Syst. 1982 Mar;5(2):177-94. doi: 10.1016/0165-1838(82)90038-8.
In conscious rabbits peripheral cold stimuli decreased respiratory rate and increased cutaneous vasomotor tone while simultaneously renal sympathetic nervous discharge decreased. Peripheral warm stimuli produced the reverse pattern of autonomic effector activity. Injection of a bacterial endotoxin at warm ambient temperature elicited a biphasic fever response. Within the first 60 min cutaneous vasomotor tone increased, simultaneously renal sympathetic activity decreased. Therefore, ear skin vessels dilated and renal sympathetic activity increased by about 100%. Respiratory rate remained depressed during both fever phases. Renal blood flow was investigated in a second series of experiments and showed a negative stimulation but only in the first phase of fever. The results show that renal innervation is involved in the typical thermoregulatory autonomic activity pattern by which temperature homeostasis is preserved. The vasomotor patterns of cold and heat stress developing during fever are compatible with the concept of a changed set-point of the body thermostat. The depressed respiratory rate and the lack of the renal vascular response to the increased nervous activity during the second fever phase and their reversal to normal after acetylsalicylate (ASA) indicate the participation of prostaglandins modifying peripheral and central neurotransmitter mechanisms.
在清醒兔中，外周冷刺激会降低呼吸频率并增加皮肤血管运动张力，同时肾交感神经放电减少。外周热刺激则产生相反的自主效应器活动模式。在温暖环境温度下注射细菌内毒素会引发双相热反应。在最初的60分钟内，皮肤血管运动张力增加，同时肾交感神经活动减少。因此，耳皮肤血管扩张，肾交感神经活动增加约100%。在两个发热阶段呼吸频率均保持降低。在第二系列实验中研究了肾血流量，结果显示仅在发热的第一阶段存在负性刺激。结果表明，肾神经支配参与了维持体温稳态的典型体温调节自主活动模式。发热期间冷应激和热应激的血管运动模式与体温调节设定点改变的概念相符。第二发热阶段呼吸频率降低以及肾血管对增加的神经活动缺乏反应，而在乙酰水杨酸（ASA）作用后恢复正常，这表明前列腺素参与了调节外周和中枢神经递质机制。
