Crockard A, Kang J, Ladds G
J Neurosurg. 1982 Aug;57(2):203-9. doi: 10.3171/jns.1982.57.2.0203.
An experimental model of focal laceration and contusion in gerbils is described. Associated with this injury are systemic changes which are neurogenically mediated and result in an immediate reduction in blood pressure, bradycardia, and generalized reduction in cerebral blood flow. There is generalized edema, as judged by a decreased specific gravity in the brain, probably related to reduced blood flow; superimposed on this, there is an edema gradient which is maximal close to the injury. This, in turn, affects the local capillary bed and prevents any local increase in flow. A separate group studied over a longer time period (6 hours) did not reveal egress of Evans blue into the surrounding tissue and this is in contrast to reports from cold-injury studies.
本文描述了沙鼠局灶性撕裂伤和挫伤的实验模型。与这种损伤相关的是全身性变化，这些变化由神经介导，导致血压立即下降、心动过缓以及脑血流量普遍减少。根据大脑比重降低判断，存在全身性水肿，这可能与血流减少有关；在此基础上，存在一个水肿梯度，在损伤部位附近最大。这反过来又影响局部毛细血管床，并阻止局部血流增加。在较长时间段（6小时）内研究的另一组未发现伊文思蓝渗入周围组织，这与冷损伤研究的报告形成对比。
