由噬菌体XP-12诱导的5-甲基-dCTP脱氨酶
5-methyl-dCTP deaminase induced by bacteriophage XP-12.
作者信息
Wang R Y, Ehrlich M
出版信息
J Virol. 1982 Apr;42(1):42-8. doi: 10.1128/JVI.42.1.42-48.1982.
Abstract
Bacteriophage XP-12, whose DNA contains 34 mol% 5-methylcytosine, induces the synthesis of a unique enzyme, 5-methyl-dCTP deaminase. The substrate for this enzyme, 5-methyl-dCTP, is produced by reactions catalyzed in part by other phage-induced enzymes, and the product of the reaction is dTTP. The deaminase therefore provides a novel pathway for biosynthesis of thymine residues for phage XP-12 DNA. Evidence is presented that this pathway is used for dTTP synthesis in XP-12-infected Xanthomonas oryzae.
摘要
噬菌体XP - 12的DNA含有34摩尔%的5 - 甲基胞嘧啶，它能诱导一种独特的酶——5 - 甲基 - dCTP脱氨酶的合成。这种酶的底物5 - 甲基 - dCTP部分是由其他噬菌体诱导酶催化的反应产生的，反应产物是dTTP。因此，这种脱氨酶为噬菌体XP - 12 DNA中胸腺嘧啶残基的生物合成提供了一条新途径。有证据表明，这条途径用于在被XP - 12感染的水稻黄单胞菌中合成dTTP。
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