Miller D P, Everett E D, Hamory B H, Haibach H, Durham J B, Kier-Schroeder A
J Urol. 1982 Jun;127(6):1230-2. doi: 10.1016/s0022-5347(17)54304-9.
Despite technical advances, Foley catheter associated urinary tract infections continue to be the leading cause of nosocomial infections. PVP-I2 has been shown to be nonirritating to abraded tissue and we have shown that dilute solutions are bactericidal for organisms causing Foley catheter associated urinary tract infections. The purpose of this study was to ascertain the toxicity of PVP-I2 on the catheterized rat bladder and to measure the systemic absorption of I2. Bladder catheters were surgically placed into each of 3 groups of rats: group 1, catheters only; group 2, irrigation with PBS q.8h; and group 3, irrigation with a 1:3 dilution of a 10 per cent PVP-1 per cent I2 solution q-8h. One-half of each group was sacrificed at 1 and 2 weeks respectively. Photographs of mounted bladders and histologic sections were then graded by 3 independent observers. Blood for protein bound iodine (PBI), T3 and T4 levels was obtained before the study and at sacrifice. No difference in ulcerations, erythema or inflammation was noted. PBI was higher in group 3 rats at conclusion than group 1 and 2 (6.88 mg./dl. versus 3.42 mg./dl.) (p less than 0.05). There was no difference in T3 or T4 levels. In this study, PVP-I2 was no more toxic to the bladder than catheterization alone or irrigation with PBS.
尽管技术不断进步，但导尿管相关的尿路感染仍然是医院感染的主要原因。聚维酮碘（PVP-I2）已被证明对擦伤组织无刺激性，并且我们已经表明稀释溶液对引起导尿管相关尿路感染的微生物具有杀菌作用。本研究的目的是确定PVP-I2对插管大鼠膀胱的毒性，并测量碘（I2）的全身吸收情况。通过手术将膀胱导管分别置入3组大鼠体内：第1组，仅置入导管；第2组，每8小时用磷酸盐缓冲液（PBS）冲洗；第3组，每8小时用10%聚维酮-1%碘溶液的1:3稀释液冲洗。每组的一半大鼠分别在1周和2周时处死。然后由3名独立观察者对固定膀胱的照片和组织学切片进行评分。在研究前和处死时采集血液检测蛋白结合碘（PBI）、三碘甲状腺原氨酸（T3）和甲状腺素（T4）水平。未观察到溃疡、红斑或炎症方面的差异。在实验结束时，第3组大鼠的PBI高于第1组和第2组（6.88毫克/分升对3.42毫克/分升）（p<0.05）。T3或T4水平没有差异。在本研究中，PVP-I2对膀胱的毒性并不比单纯插管或用PBS冲洗更大。
