海马体点燃及抗癫痫药物的作用

Hippocampal kindling and effects of antiepileptic drugs.

作者信息

Aihara H, Araki H, Ohzeki M

出版信息

Jpn J Pharmacol. 1982 Feb;32(1):37-45. doi: 10.1254/jjp.32.37.

DOI:10.1254/jjp.32.37

Abstract

The kindling effect of the hippocampus was investigated in rats. The development of behavioral manifestations in hippocampal kindling was similar to that seen in the case of amygdaloid kindling, but many more stimulations were required to evoke behavioral convulsions in the former. The transfer phenomenon from amygdala to hippocampus was evident. There were no differences in effects of drugs on the seizure-discharge and the behavioral convulsions between the amygdaloid and the hippocampal kindled rats. The present results suggest that the amygdala plays an important role in the formation of hippocampal kindling, especially in the manifestation of behavioral changes. The hippocampal kindled rat, as well as amygdaloid kindled rat, is useful animal model for evaluating the antiepileptic effect of various drugs.

摘要

在大鼠中研究了海马的点燃效应。海马点燃中行为表现的发展与杏仁核点燃的情况相似，但前者需要更多的刺激才能诱发行为性惊厥。从杏仁核到海马的转移现象很明显。在杏仁核点燃和海马点燃的大鼠中，药物对癫痫放电和行为性惊厥的影响没有差异。目前的结果表明，杏仁核在海马点燃的形成中起重要作用，特别是在行为变化的表现方面。海马点燃大鼠以及杏仁核点燃大鼠都是评估各种药物抗癫痫作用的有用动物模型。