饥饿对雄性大鼠二氢睾酮 - 促黄体生成素反馈的影响。

Influence of starvation on the dihydrotestosterone-luteinizing hormone feedback in the male rat.

作者信息

Pirke K M, Baraño J L, Calandra R, Lüthy I, Spyra B

出版信息

J Steroid Biochem. 1982 Mar;16(3):403-6. doi: 10.1016/0022-4731(82)90052-8.

Abstract

The suppressing effect of dihydrotestosterone (DHT) on LH secretion in freshly castrated starved and control rats was studied by implanting DHT releasing silastic capsules of various sizes. Lower plasma levels of DHT are needed to suppress the castration induced LH increase in the starved animals. Intravenous injection of tritiated testosterone (18 muCi/100 g b.wt) revealed a significantly longer half-life (12.4 vs 8.9; P less than 0.05) in the starved rat. The ratio [3H]-DHT/[3H]-T in plasma at various times after injection was not significantly different in starved and control animals. The results indicate that the increased sensitivity of the T-LH feedback report earlier [1] cannot be explained by a greater conversion T-DHT in the starved male rat.

摘要

通过植入不同大小的释放双氢睾酮（DHT）的硅橡胶胶囊，研究了双氢睾酮（DHT）对刚去势的饥饿大鼠和对照大鼠促黄体生成素（LH）分泌的抑制作用。抑制饥饿动物去势诱导的LH升高所需的DHT血浆水平较低。静脉注射氚标记的睾酮（18μCi/100g体重）显示，饥饿大鼠的半衰期明显更长（12.4对8.9；P<0.05）。注射后不同时间血浆中[3H]-DHT/[3H]-T的比值在饥饿动物和对照动物中无显著差异。结果表明，早期[1]报道的T-LH反馈敏感性增加不能用饥饿雄性大鼠中T向DHT的更大转化率来解释。