Chandler R F, Hooper S N, Hooper D L, Jamieson W D, Lewis E
Lipids. 1982 Feb;17(2):102-6. doi: 10.1007/BF02535183.
Plant sterols and triterpenes exhibit a wide range of pharmacological activities. As part of our ongoing studies of the medicinal aspects of Maritime flora, particularly the herbal remedies of the Micmac and Malecite Indians, we determined the nature of the sterols and triterpenes of Tanacetum vulgare L. (Compositae)-a widely used herbal remedy usually referred to as tansy. By using thin layer and gas chromatographics, nuclear magnetic resonance (NMR) spectroscopy and combined gas chromatography-mass spectrometry, we were able to identify beta-sitosterol as the major sterol and alpha-amyrin as the major triterpene of tansy. We also identified the sterols stigmasterol, campesterol and cholesterol, and the triterpenes beta-amyrin and taraxasterol. A fourth triterpene was tentatively identified as pseudo-taraxasterol. The successful therapeutic application of this herb may be due partly to the presence of one or more of these compounds. The sterols and triterpenes of tansy have not been previously reported; neither, to our knowledge, have the NMR spectra of the amyrins and the NMR and mass spectra of taraxasterol.
植物甾醇和三萜类化合物具有广泛的药理活性。作为我们对海洋植物药用特性持续研究的一部分，特别是对密克马克族和马莱西特族印第安人草药疗法的研究，我们确定了菊蒿（菊科）——一种通常被称为艾菊的广泛使用的草药——中甾醇和三萜类化合物的性质。通过使用薄层色谱法、气相色谱法、核磁共振（NMR）光谱法以及气相色谱 - 质谱联用技术，我们能够鉴定出β - 谷甾醇是艾菊中的主要甾醇，α - 香树脂醇是主要的三萜类化合物。我们还鉴定出了豆甾醇、菜油甾醇和胆固醇等甾醇，以及β - 香树脂醇和蒲公英甾醇等三萜类化合物。第四个三萜类化合物初步鉴定为假蒲公英甾醇。这种草药的成功治疗应用可能部分归因于这些化合物中的一种或多种的存在。艾菊中的甾醇和三萜类化合物此前尚未见报道；据我们所知，香树脂醇的核磁共振光谱以及蒲公英甾醇的核磁共振光谱和质谱也未见报道。
