Synthesis of N7-hydroxyethylguanine and O6-hydroxyethylguanine. Markers for the reaction of ethylene oxide (EO) with DNA.
作者信息
Ashby J, Paton D, Styles J A, Greatbanks D, Wright B
出版信息
Mutat Res. 1982 Mar;103(3-6):257-61. doi: 10.1016/0165-7992(82)90051-3.
PMID:7087988
Abstract
O6-Hydroxyethylguanine has been synthesized by reaction of mono-sodium glycolate with 6-chloroguanine. The crystalline product has been characterized using a variety of analytical techniques and compared with a sample of the corresponding N7-hydroxyethyl derivative. These 2 chemicals may prove useful as standards when studying the reaction of ethylene oxide (EO) with DNA.
摘要
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