Ikeda K, Hiraoka M
Pflugers Arch. 1982 Mar;393(1):45-50. doi: 10.1007/BF00582390.
The effect of hypoxia, either in the presence or in the absence of glucose, on the passive electrical properties of canine ventricular muscle fibers was examined, employing a single sucrose gap method. The significant changes after 30 min of hypoxia (PO2 = 35-45 mm Hg) were an increase in the specific internal longitudinal resistance (Ri) and a decrease in the space constant (lambda). The values during the control (PO2 greater than 450 mm Hg) were 198 +/- 77 omega cm for Ri and 0.81 +/- 0.15 mm for lambda, and they changed to 245 +/- 90 omega cm and 0.70 +/- 0.10 mm, respectively, after 30 min of hypoxia. Hypoxia decreased the specific membrane resistance (Rm), but the changes were not statistically significant. The membrane time constant (tau m) and capacity (Cm) were not affected significantly. The absence of glucose during hypoxia was found to cause more profound changes than hypoxia alone in the passive electrical properties, especially Ri and lambda, suggesting that glucose might counteract the effects of hypoxia on these parameters of ventricular muscles.
采用单蔗糖间隙法，研究了在有葡萄糖和无葡萄糖情况下，缺氧对犬心室肌纤维被动电特性的影响。缺氧30分钟（PO2 = 35 - 45 mmHg）后的显著变化是比内部纵向电阻（Ri）增加和空间常数（lambda）减小。对照期间（PO2大于450 mmHg），Ri的值为198±77Ω·cm，lambda的值为0.81±0.15 mm，缺氧30分钟后，它们分别变为245±90Ω·cm和0.70±0.10 mm。缺氧降低了比膜电阻（Rm），但变化无统计学意义。膜时间常数（tau m）和电容（Cm）未受到显著影响。发现缺氧期间无葡萄糖比单独缺氧在被动电特性方面，特别是Ri和lambda，会引起更深刻的变化，这表明葡萄糖可能抵消缺氧对心室肌这些参数的影响。
