Zakusov V V, Kostochka L M, Skoldinov A P
Biull Eksp Biol Med. 1978 Oct;86(10):435-8.
The influence of ecgonine, tropine, tropinon, and some of their derivatives, propan, N-methylpyrrholidine, N-methylpiperidine on impulse summation in the central nervous system, conditioned reflex of avoidance, antagonism to hexenal, synergisim to cocaine and also their toxicity (LD50) have been studied under experimental conditions. As shown, benzoyl-ecgonine, ecgonine methyl ester, ecgonine, tropine, pseudotropine, carbomethoxytropinon, tropinon, tropine, tropan N-methylpyrrolidine, and N-methylpiperidine produced a pronounced stimulating effect on the central nervous system activity; in this respect they were similar to cocaine. The following conclusions were made: the substances whose molecules contained tropan structure or one of its fragments possess the central stimulating effect. The stimulating effect of cocaine on the central nervous system could be due to the tropan fragment of its molecule.
在实验条件下，已研究了爱康宁、托品碱、托品酮及其某些衍生物丙胺、N-甲基吡咯烷、N-甲基哌啶对中枢神经系统冲动总和、回避条件反射、对己烯醛的拮抗作用、对可卡因的协同作用以及它们的毒性（半数致死量）。结果表明，苯甲酰爱康宁、爱康宁甲酯、爱康宁、托品碱、假托品碱、甲氧羰基托品酮、托品酮、托品碱、托烷N-甲基吡咯烷和N-甲基哌啶对中枢神经系统活动产生了明显的刺激作用；在这方面它们与可卡因相似。得出以下结论：其分子含有托烷结构或其片段之一的物质具有中枢刺激作用。可卡因对中枢神经系统的刺激作用可能归因于其分子中的托烷片段。
