Pousette A, Björk P, Carlström K, Forsgren B, Högberg B, Gustafsson J A
Prostate. 1982;3(2):109-14. doi: 10.1002/pros.2990030202.
Prostatic secretion protein (PSP) is an androgen-sensitive, quantitatively important protein in rat ventral prostate which has been shown to inhibit the nuclear uptake and decrease the DNA-binding capacity of the androgen-receptor complex. In the present study, the influence of the pituitary, adrenals, and gonads on the concentration of PSP in the prostate was studied. Hypophysectomy decreased the concentration of PSP to about 10% of the control level, an effect similar to that obtained by castration. No effects on prostatic wet weight or PSP concentration were observed following substitution of hypophysectomized rats with human growth hormone, rat prolactin, or rat growth hormone. On the other hand, PSP concentration as well as wet weight of the prostate were normalized in hypophysectomized rats after administration of testosterone propionate. These results are in line with a direct extrahypophyseal effect of androgens on the prostate. Adrenalectomy did not affect the concentration of PSP, nor the wet weight of the prostate. Administration of estramustine decreased the wet weight of the prostate but did not affect the prostatic concentration of PSP in normal rats. Combined treatment with testosterone propionate and estramustine seemed to increase both the wet weight and the concentration of PSP more than administration of testosterone propionate alone. These results indicate a synergistic effect between estramustine and testosterone propionate.
前列腺分泌蛋白（PSP）是大鼠前列腺中一种对雄激素敏感且在数量上具有重要意义的蛋白质，已被证明能抑制雄激素受体复合物的核摄取并降低其DNA结合能力。在本研究中，研究了垂体、肾上腺和性腺对前列腺中PSP浓度的影响。垂体切除使PSP浓度降至对照水平的约10%，这一效果与去势相似。用人生长激素、大鼠催乳素或大鼠生长激素替代垂体切除的大鼠后，未观察到对前列腺湿重或PSP浓度的影响。另一方面，给予丙酸睾酮后，垂体切除大鼠的PSP浓度以及前列腺湿重恢复正常。这些结果与雄激素对前列腺的直接垂体外作用一致。肾上腺切除不影响PSP浓度，也不影响前列腺湿重。给予雌莫司汀可降低前列腺湿重，但不影响正常大鼠前列腺中PSP的浓度。丙酸睾酮和雌莫司汀联合治疗似乎比单独给予丙酸睾酮更能增加前列腺湿重和PSP浓度。这些结果表明雌莫司汀和丙酸睾酮之间存在协同作用。
