Smith W D, Jackson E, Jackson F
Res Vet Sci. 1982 Jan;32(1):101-5.
Mature sheep immunised with two doses of 10,000 irradiated Ostertagia circumcincta larvae were only slightly resistant to challenge with a single dose of 10,000 larvae. This slight resistance was abolished if the 'vaccine' worm population was removed one week before challenge. In contrast, seven of eight sheep immunised with irradiated Haemonchus contortus larvae were highly resistant to homologous challenge. Evidence of some cross protection against challenge with O circumcinta was observed in five of six sheep immunised with irradiated H contortus in that egg counts were lower and more worms were retarded as fourth stage larvae.
用两剂10,000条经辐照的环形奥斯特他线虫幼虫免疫的成年绵羊，对单剂量10,000条幼虫的攻击仅有轻微抵抗力。如果在攻击前一周清除“疫苗”虫群体，则这种轻微抵抗力就会消失。相比之下，用经辐照的捻转血矛线虫幼虫免疫的八只绵羊中有七只对同源攻击具有高度抵抗力。在用经辐照的捻转血矛线虫免疫的六只绵羊中，有五只观察到了对环形奥斯特他线虫攻击的某种交叉保护证据，即虫卵计数较低，并且更多的虫体在第四期幼虫阶段发育受阻。
