非甾体抗炎药对老年人肾功能的影响。
Effects of nonsteroidal anti-inflammatory drugs on renal function in the elderly.
作者信息
Stewart R B, Hale W E, Marks R G
出版信息
South Med J. 1982 Jul;75(7):824-6. doi: 10.1097/00007611-198207000-00015.
The effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on estimated creatinine clearance (ECC) was studied in a large ambulatory elderly population. ECC of participants using eight different NSAIDs and that of a control group using no drugs were compared. With one exception, ECCs of subjects using NSAIDs were lower than those of subjects using no medications. Results of this study suggest that long-term treatment with NSAIDs results in a decrease in renal function, and the effect on renal function may not be the same with all agents.
在一大群老年门诊患者中研究了非甾体抗炎药（NSAIDs）对估计肌酐清除率（ECC）的影响。比较了使用八种不同NSAIDs的参与者与未用药的对照组的ECC。除了一种情况外，使用NSAIDs的受试者的ECC低于未用药的受试者。这项研究的结果表明，长期使用NSAIDs会导致肾功能下降，而且并非所有药物对肾功能的影响都是相同的。
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