• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Metabolism of paracetamol by the isolated perfused kidney of the homozygous Gunn rat.

作者信息

Emslie K R, Calder I C, Hart S J, Tange J D

出版信息

Xenobiotica. 1982 Feb;12(2):77-82. doi: 10.3109/00498258209046780.

DOI:10.3109/00498258209046780
PMID:7090424
Abstract
  1. Isolated kidneys from homozygous Gunn rats were perfused with paracetamol in concentrations lower and higher than Km for paracetamol oxidation in the albino rat kidney. 2. Glucuronylation of paracetamol was not detected at either concentration. 3. An increase in oxidative metabolism at the higher concentration, similar to that seen with the Sprague-Dawley rat kidney, did not occur with kidneys from homozygous Gunn rats. 4. This finding does not support the hypothesis that the enhanced nephrotoxicity of paracetamol observed in the homozygous Gunn rat in vivo is due to increased intrarenal formation of reactive metabolites.
摘要

相似文献

1
Metabolism of paracetamol by the isolated perfused kidney of the homozygous Gunn rat.
Xenobiotica. 1982 Feb;12(2):77-82. doi: 10.3109/00498258209046780.
2
The influence of metabolic variation on analgesic nephrotoxicity. Experiments with the Gunn rat.
Pathology. 1982 Oct;14(4):349-53. doi: 10.3109/00313028209092108.
3
Enhanced acetaminophen toxicity in rats with bilirubin glucuronyl transferase deficiency.
Hepatology. 1989 Aug;10(2):163-7. doi: 10.1002/hep.1840100207.
4
Paracetamol and the isolated perfused kidney: metabolism and functional effects.对乙酰氨基酚与离体灌流肾：代谢及功能影响
Xenobiotica. 1981 Jan;11(1):43-50. doi: 10.3109/00498258109045270.
5
Renal metabolism of paracetamol: studies in the isolated perfused rat kidney.对乙酰氨基酚的肾脏代谢：在离体灌注大鼠肾脏中的研究
Clin Sci (Lond). 1980 May;58(5):379-84. doi: 10.1042/cs0580379.
6
Hepatotoxicity of phenacetin and paracetamol in the Gunn rat.非那西丁和对乙酰氨基酚对冈恩大鼠的肝毒性
Pathology. 1981 Oct;13(4):757-62. doi: 10.3109/00313028109086649.
7
Deficiency in bilirubin UDP-glucuronyl transferase as a genetic determinant of acetaminophen toxicity.胆红素UDP-葡萄糖醛酸基转移酶缺乏作为对乙酰氨基酚毒性的遗传决定因素。
J Pharmacol Exp Ther. 1988 Oct;247(1):323-31.
8
Induction of paracetamol metabolism in the isolated perfused kidney.对乙酰氨基酚在离体灌注肾中代谢的诱导作用。
Xenobiotica. 1981 Sep;11(9):579-87. doi: 10.3109/00498258109045869.
9
Effect of blue light on the urinary excretion of tryptophan metabolites in adult heterozygous and homozygous Gunn rats.蓝光对成年杂合和纯合Gunn大鼠色氨酸代谢产物尿排泄的影响。
Boll Soc Ital Biol Sper. 1981 Oct 15;57(19):1969-75.
10
Paracetamol metabolism by the isolated perfused rat kidney.对乙酰氨基酚在离体灌注大鼠肾脏中的代谢。
Kidney Int. 1980 Nov;18(5):562-70. doi: 10.1038/ki.1980.174.

引用本文的文献

1
The metabolism and toxicity of paracetamol in Sprague-Dawley and Wistar rats.对乙酰氨基酚在斯普拉格-道利大鼠和Wistar大鼠体内的代谢与毒性
Eur J Drug Metab Pharmacokinet. 1982;7(3):203-22. doi: 10.1007/BF03189567.