Gerlach H, Feist H, Holzhausen H J, Koch E
Zentralbl Allg Pathol. 1982;126(1-2):105-12.
A report on clinical course and morphological findings in a case of Alexander's disease is given in a boy aged 4 year and 6 months. The disease started in the second month with progressive retardation. At the age of 13 months, a ventriculo-peritoneal shunt was performed because of dilatation of ventricles. Death occurred due to cerebral dysfunction. Microscopic investigation showed a considerable demyelination and the presence of numerous Rosenthal fibers. The results are compared with observations in the literature of Alexander's disease during early infancy.
本文报告了一名4岁6个月男童亚历山大病的临床病程及形态学表现。该病于第二个月起病，伴有进行性发育迟缓。13个月大时，因脑室扩张进行了脑室-腹腔分流术。患儿最终因脑功能障碍死亡。显微镜检查显示有明显的脱髓鞘现象及大量罗森塔尔纤维。本文将这些结果与婴儿早期亚历山大病的文献观察结果进行了比较。
