Bernstein K, Schreiber D, Schneider J
Zentralbl Allg Pathol. 1982;126(1-2):53-63.
Among 737 malignant tumors, 93 (12.6%) cases showed metastases within the brain substance. There was no predominance for one of the both hemispheres. However, the cerebellum was a privileged site for metastases (48 out of 93 cases, 51.6%). Multiple metastatic nodules of the brain were found in 65 cases; single metastases occurred 18 times (ratio 3.6 to 1). 11 cases displayed a carcinosis of the leptomeninges and 5 a carcinosis of the brain (table 3). Within the cerebrum we observed 1,060 metastatic nodules (fig. 1). 210 secondary deposits, i.e. one sixth of all nodules, were localized in the cerebellum. Concerning the distribution patterns of the metastases, it is remarkable that an increasing frequency of nodules was seen from the frontal lobes (241) to the parietal (259) and occipital lobes (276), whereas the temporal lobes (146) were significantly less affected. 936 out of a total of 1,270 brain metastases (73.7%) showed a size of the nodules not larger than a pea (table 8.) The source of more than two thirds of all metastatic deposits (875/1,270 = 68.9%) was a carcinoma of the lung (bronchial carcinoma, resp.). With the exception of metastases in the pituitary gland, pineal gland and choroid plexus (compare with the 3rd communication on CNS metastases) 18.6 metastatic brain nodules were observed per lung carcinoma. However, the highest frequency per case with brain metastases was registered in thyroid cancer (40 nodules, table 8).
在737例恶性肿瘤中，93例（12.6%）出现脑实质内转移。两侧半球无明显优势。然而，小脑是转移的好发部位（93例中有48例，占51.6%）。65例发现脑内多发转移结节；单发转移18例（比例为3.6比1）。11例出现软脑膜癌病，5例出现脑癌病（表3）。在大脑中我们观察到1060个转移结节（图1）。210个继发性病灶，即所有结节的六分之一，位于小脑。关于转移的分布模式，值得注意的是，从额叶（241个）到顶叶（259个）和枕叶（276个），结节出现的频率增加，而颞叶（146个）受影响明显较少。在总共1270个脑转移瘤中，936个（73.7%）结节大小不超过豌豆（表8）。所有转移病灶中超过三分之二（875/1270 = 68.9%）的来源是肺癌（分别为支气管癌）。除垂体、松果体和脉络丛转移（与关于中枢神经系统转移的第三次通讯比较）外，每例肺癌观察到18.6个脑转移结节。然而，脑转移患者中每例出现结节频率最高的是甲状腺癌（40个结节，表8）。
