Itami R M, Amundson G M, Kaplan S A, Lippe B M
Am J Dis Child. 1982 Jul;136(7):584-6. doi: 10.1001/archpedi.1982.03970430016004.
Prepubertal gynecomastia is a rare disorder that may be associated with adrenal or testicular tumors. An adrenal tumor causing a mixed feminizing-virilizing syndrome in a 6-year-old boy was identified by ultrasonography, whereas excretory urography failed to show any abnormality. Highly elevated estrone concentrations were found in the plasma, as were more modestly increased levels of estradiol, testosterone, androstenedione, and 11-deoxycortisol. After removal of the tumor, all hormonal concentrations returned to normal prepubertal levels.
青春期前男性乳房发育症是一种罕见的疾病，可能与肾上腺或睾丸肿瘤有关。一名6岁男孩因肾上腺肿瘤导致了女性化 - 男性化混合综合征，通过超声检查得以确诊，而排泄性尿路造影未显示任何异常。血浆中发现雌酮浓度大幅升高，雌二醇、睾酮、雄烯二酮和11 - 脱氧皮质醇水平也有适度升高。切除肿瘤后，所有激素浓度均恢复到青春期前的正常水平。
