Edidin D V, Levitsky L L
Am J Dis Child. 1982 Jul;136(7):587-8. doi: 10.1001/archpedi.1982.03970430019005.
Gynecomastia associated with high plasma estrogen levels was observed in a prepubertal boy. The family initially denied ingestion or application of any medications despite careful review of the history, but endocrinologic findings were not consistent with endogenous estrogen production. Persistent inquiry discovered the use of a hair cream containing substantial amounts of estrogen. After discontinuation of its use, breast tissue regressed and estrogen levels returned to normal. To our knowledge, scalp inunction has not hitherto been reported as a cause of prepubertal gynecomastia.
在一名青春期前男孩中观察到与高血浆雌激素水平相关的男性乳腺增生。尽管仔细询问了病史，但其家人最初否认摄入或使用过任何药物，但内分泌学检查结果与内源性雌激素生成不符。持续追问发现其使用了一种含有大量雌激素的发乳。停用该发乳后，乳腺组织消退，雌激素水平恢复正常。据我们所知，头皮涂抹迄今尚未被报道为青春期前男性乳腺增生的病因。
